Keywords :
adiponectin, chronic periodontitis, type 2 diabetes mellitus, scaling and root planing
Citation Information :
Aggarwal K, Sood S, Bhaskar N, Gupta M, Kapur V. Effect of Nonsurgical Periodontal Therapy on Adiponectin Levels in Type 2 Diabetics with Moderate to Severe Chronic Periodontitis-A Pilot Trial. 2022; 10 (3):145-149.
Background Adiponectin is a novel adipocyte-specific protein, which plays an important role in decreasing insulin resistance and inflammation, and hence can be considered in understanding the underlying mechanisms of both diabetes and periodontitis. As periodontitis and diabetes mellitus share common pathways of pathogenesis, this study was conducted to determine the effect of nonsurgical periodontal therapy on adiponectin levels in type 2 diabetics with moderate to severe chronic periodontitis.
Material and Methods Ten poorly controlled type 2 diabetics (hemoglobin A1c [HbA1c] ≥ 6.5%) with moderate to severe periodontitis (test group) and 10 age, sex, and body mass index matched systemically healthy patients with moderate to severe periodontitis (control group) were recruited. All the subjects underwent nonsurgical periodontal therapy. Gingival crevicular fluid (GCF) and serum were collected at the baseline and 3 months after periodontal treatment for assessment of adiponectin levels.
Results Adiponectin levels increased postperiodontal therapy in both the groups, both in GCF (p = 0.206, 0.12) and serum (p = 0.051, 0.06). HbA1c reduced in the test group posttreatment (p = 0.229).
Conclusion Nonsurgical periodontal therapy affects adiponectin levels locally as well as systemically thereby leading to improvement of glycemic control.
Association of circulating leptin and adiponectin with periodontitis: a systematic review and metaanalysis. BMC Oral Health 2017;17(01):104
Adiponectin and its association with insulin resistance and type 2 diabetes. J Genet Genomics 2008;35(06):321–326
Adiponectin–it's all about the modifications. Int J Biochem Cell Biol 2010;42(06):785–788
Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women. J Intern Med 2011;269(06):636–643
Evidence that periodontal treatment improves diabetes outcomes: a systematic review and metaanalysis. J Clin Periodontol 2013;40(Suppl 14):S153–S163
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care 2019;42(Suppl 1):S13–S28
Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4(01): 1–6
ler L, Buduneli N, Cetinkalp S, Kinane DF. Adipokines and inflammatory mediators after initial periodontal treatment in patients with type 2 diabetes and chronic periodontitis. J Periodontol 2010;81(01): 24–33
Formation, collection and significance of gingival crevice fluid. Periodontol 2000 2003;31: 32–42
Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2009;302(02): 179–188
Meta-analysis of adiponectin as a biomarker for the detection of metabolic syndrome. Front Physiol 2018;9:1238
Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis. Arch Oral Biol 2010;55(12): 970–974
Gingival crevicular fluid levels of resistin and adiponectin in chronic periodontitis with type 2 diabetes mellitus. J Int Dent Med Res 2016;9:x
Adipocytokines in obesity and metabolic disease. J Endocrinol 2014;220(02):T47.T59
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008;29 (24): 2959–2971
Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-ƒ¿ expression. Diabetes 2003;52(07): 1779–1785
Tumor necrosis factor-ƒ¿ suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-ƒ¿ is obligatory. Diabetes 2002;51(05): 1319–1336
Adiponectin and inflammation: consensus and controversy. J Allergy Clin Immunol 2008;121(02): 326–330
Local and systemic level of adipokines as markers of inflammation in periodontitis and type 2 diabetes mellitus after periodontal therapy. Tanta Dent J 2019;16:104
Risk factors for periodontal disease. Periodontol 2000 2013;62(01): 59–94
Nonsurgical periodontal therapy: a review. J Oral Res Rev 2016;8:39
Role of periodontal therapy in management of common complex systemic diseases and conditions: an update. Periodontol 2000 2018; 78(01): 212–226
