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VOLUME 11 , ISSUE 3 ( September-December, 2023 ) > List of Articles

Original Article

Oral Manifestations in COVID-19 Patients: A Prevalence Study

Alice Lyngdoh, Sougaijam Vijay Singh, Lomtu Ronrang, Nathaniel Kharumnuid, Roshnee Bhattacharya

Keywords : COVID-19, Oral lesions, Oral symptoms

Citation Information : Lyngdoh A, Singh SV, Ronrang L, Kharumnuid N, Bhattacharya R. Oral Manifestations in COVID-19 Patients: A Prevalence Study. 2023; 11 (3):111-115.

DOI: 10.5005/djas-11014-0025

License: CC BY-NC-ND 4.0

Published Online: 30-12-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Introduction: Coronavirus disease has manifestations in multiple systems with the respiratory system being predominantly the first system to be affected, it is important to know whether coronavirus disease has primary oral manifestations or whether the oral manifestations were due to an overwhelming response to the disease. Understanding its oral manifestations will lead to early diagnosis and proper isolation that may reduce the spread and severity of the disease. Materials and methods: The study participants were selected among recovered COVID-19 patients. The participants were interviewed through preset questionnaires through telephonic conversation. Oral examination was done only for patients who had negative RTPCR testing from COVID-19 and were still being admitted to the hospital for full recovery. Results: There were 200 participants, 119 were females and 81 were males. There were oral lesions, such as ulcers, thrush, mucositis, or a combination thereof, observed in 14 patients. Among the 116 patients, oral symptoms such as ageusia were most prominent, with oral lesions and other oral issues being more prevalent in symptomatic individuals and those with systemic conditions compared to asymptomatic and healthy individuals. Conclusion: The oral manifestations among COVID-19 patients were statistically insignificant due to limited data. However, it was observed that taste alteration is most common and may be associated with COVID-19. The oral lesions are highly likely to be secondary manifestations of the disease.

  1. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral manifestations in patients with COVID-19. A living systematic review. Journal of Dental Research 2021;100(2):141–154. DOI: 10.1177/0022034520957289.
  2. Halboub E, Al-Maweri SA, Alanazi RH, et al. Orofacial manifestations of COVID-19: A brief review of the published literature. Braz Oral Res 2020;34:e124. DOI: 10.1590/1807-3107bor-2020.vol34.0124.
  3. Wang MK, Yu XL, Zhou LY, et al. COVID-19 and liver dysfunction: What nutritionists need to know. World J Gastroenterol 2022;28(15): 1526–1535. DOI: 10.3748/wjg.v28.i15.1526.
  4. Czumbel LM, Kiss S, Farkas N, et al. Saliva as a candidate for COVID-19 diagnostic testing: A meta-analysis. Front Med (Lausanne) 2020;7:465. DOI: 10.3389/fmed.2020.00465.
  5. Hung KF, Sun YC, Chen BH, et al. New COVID-19 saliva-based test: How good is it compared with the current nasopharyngeal or throat swab test? J Chin Med Assoc 2020;83(10):891–894. DOI: 10.1097/JCMA.0000000000000396.
  6. El Kady DM, Gomma EA, Abdella WS, et al. Oral manifestations of COVID-19 patients: An online survey of the Egyptian population. Clin Exp Dent Res 2021;7(5):852–860. DOI: 10.1002/cre2.429.
  7. Elamrousy WAH, Nassar M, Issa DR. Prevalence of Oral Lesions in COVID-19 Egyptian patients. J Int Soc Prev Community Dent 2021;11(6):712–720. DOI: 10.4103/jispcd.JISPCD_221_21.
  8. Finsterer J, Stollberger C. Causes of hypogeusia/hyposmia in SARS-CoV2 infected patients. J Med Virol 2020;92(10):1793–1794. DOI: 10.1002/jmv.25903.
  9. Mariz BALA, Brandão TB, Ribeiro ACP, et al. New insights for the pathogenesis of COVID-19-related dysgeusia. J Dent Res 2020;99(10):1206. DOI: 10.1177/0022034520936638.
  10. Kinnamon SC, Cummings TA. Chemosensory transduction mechanisms in taste. Annu Rev Physiol 1992;54:715–731. DOI: 10.1146/
  11. Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus: A first step in understanding SARS pathogenesis. J Pathol 2004;203(2):631–637. DOI: 10.1002/path.1570.
  12. Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020;12(1):8. DOI:
  13. Nataf S. An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID-19. J Med Virol 2020;92(10):1743–1744. DOI: 10.1002/jmv.25826.
  14. Aragoneses J, Suarez A, Algar J, et al. Oral manifestations of COVID 19: Updated systematic review with meta-analysis. Frontiers in medicine 2021;8:726753. DOI: 10.3389/fmed.2021.726753.
  15. Ramires M, Mattia MB, Tateno RY, et al. Combination of phototherapy modalities for extensive lip lesions in a patient with SARS-CoV-2 infection. Photodiagnosis Photodyn Ther 2021;33:102196. DOI: 10.1016/j.pdpdt.2021.102196.
  16. Amorim Dos Santos J, Normando AGC, Carvalho da Silva RL, et al. Oral mucosal lesions in a COVID-19 patient: New signs or secondary manifestations? Int J Infect Dis 2020;97:326–328. DOI: 10.1016/j.ijid.2020.06.012.
  17. Kitakawa D, Oliveira FE, De Castro PN, et al. Short report–Herpes simplex lesion in the lip semi mucosa in a COVID-19 patient. Eur Rev Med Pharmacol Sci 2020;24(17):9151–9153. DOI: 10.26355/eurrev_202009_22863.
  18. Cuevas-Gonzalez MV, Espinosa–Cristobal LF, Donohue-Cornejo A, et al. COVID-19 and its manifestations in the oral cavity: A systematic review. Medicine (Baltimore) 2021;100(51):e28327. DOI: 10.1097/MD.0000000000028327.
  19. Samaranayake L, Fakhruddin KS, Bandara N. Oral Manifestations of corona virus Disease 2019 (COVID-19): An overview. Dental Update 2021;48(5):418–422. DOI: 10.12968/denu.2021.48.5.418.
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