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VOLUME 2 , ISSUE 3 ( September-December, 2014 ) > List of Articles

Original Article

The Effect of Non Surgical Periodontal Therapy on the Serum C Reactive Protein Levels in Generalized Chronic Periodontitis Patients: A Clinical Study

Anish Manocha, DK Suresh, Shikha Gupta, Sharuti Yakhmi, Aashish Pandit

Keywords : C-reactive protein, Periodontitis, CRP, Inflammatory marker, Periodontal therapy

Citation Information : Manocha A, Suresh D, Gupta S, Yakhmi S, Pandit A. The Effect of Non Surgical Periodontal Therapy on the Serum C Reactive Protein Levels in Generalized Chronic Periodontitis Patients: A Clinical Study. 2014; 2 (3):157-161.

DOI: 10.1055/s-0038-1672003

License: NA

Published Online: 12-05-2023

Copyright Statement:  NA


Background: Although many studies have compared circulating IL-6 and CRP concentrations in periodontal patients and controls, a limited number of studies have compared systemic inflammatory markers at baseline and follow-up and also Data on whether periodontal therapy affects serum CRP levels are inconclusive. Aims and Objective: By the virtue of this study, an attempt was made to evaluate and compare the effect of non surgical periodontal therapy on serum C-Reactive Protein levels in Generalized chronic periodontitis patients. Material and Method: A total of thirty patients with Generalised chronic periodontitis, within the age range of 30-70 years, were selected and underwent non surgical periodontal therapy. Further, they were put on a two month follow up after post operative phase for evaluation and comparison of pre and post values. Results and Conclusion: The results of our study showed that non surgical periodontal therapy significantly reduces the serum levels of C-reactive protein along with other clinical parameters in patients with generalised chronic periodontitis.

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  1. Inflammation as a cardiovascular risk factor. Circulation 2004; 109 (21, Suppl 1) II 2- II 10.
  2. Direct pro-inflammatory effect of C-reactive protein on human endothelial cells. Circulation 2000; 102: 2165-2168.
  3. C-reactive protein: Linking inflammation to cardiovascular complications. Circulation 2001; 104: 974-975.
  4. C-reactive protein: A surrogate risk marker or mediator of atherothrombosis. Am J Physiol Regul Integr Comp Physiol 2003; 285: R1250- R1252.
  5. Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J 2003; 24: 2099-2107.
  6. Relationship of destructive periodontal disease to the acute-phase response. J Periodontol 2003; 74: 1007-1016.
  7. Effect of treatment of chronic periodontitis on levels of serum markers of acute-phase inflammatory and vascular responses. J Clin Periodontol 2003; 30: 334-340.
  8. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: Results from a randomized controlled clinical trial. Am Heart J 2006; 151: 977-984.
  9. Persistently raised C-reactive protein levels are associated with advanced periodontal disease. J Clin Periodontol. 2008 Sep;35(9):741-747.
  10. Effects of treating periodontitis on C-reactive protein levels: A pilot study. BMC Infect Dis 2002; 2: 30-33.
  11. Serological reactions in pneumonia with a non protein somatic fraction of pneumococcus. J Exp Med 1930; 52: 561–585.
  12. The occurrence during acute infections of a protein not normally present in the blood. - Distribution of the reactive protein in patients' sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus. J Exp Med 1941; 73:173-82.
  13. Treatment of periodontitis and endothelial function. N Engl J Med 2007; 356: 911-920.
  14. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res. 2000 Jan; 79 (1): 49-57.
  15. Periodontal infections contribute to elevated systemic C-Reactive protein level. J Periodontol 2001; 72: 1221–1227.
  16. Salivary levels of α2-macroglobulin, α1-antitrypsin, C-reactive protein, cathepsin G and elastase in humans with or without destructive periodontal disease. Archives of Oral Biology 1995; 40: 1151-1155.
  17. Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. J Periodont Res 2005; 40: 53–58.
  18. Antimicrobial periodontal treatment decreases serum C reactive protein, Tumor Necrosis factor á but not adiponectin levels in patients with chronic periodontitis. J Periodontol 2003: 74: 1231–1236.
  19. The effects of periodontal therapy on vascular endothelial function: a pilot trial. Am Heart J. 2006 Jan;151(1):47.
  20. Impact of C-reactive protein on disease risk and its relation to dietary factors. Asian Pac J Cancer Prev 2007; 8(2):167-177.
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