Epigenetics is the study of potentially heritable changes in gene expression that does not involve changes in underlying DNA sequence. Epigenetic mechanisms play a crucial role in cellular proliferation, migration, and differentiation in both normal and neoplastic development. Epigenetic changes may be inherited and can occur during embryonal development or after birth. Once the change in DNA methylation takes place, following cell division the altered pattern is transferred into daughter cells by the action DNA methyltransferase enzyme, which recognizes hemi-methylated sites and methylates newly synthesized DNA formed during replication. Recently, it has been suggested that aberrant DNA methylation of cytosine-phosphate-guanine (CpG) islands is a common event in odontogenic tumors. Expression of DNA methyltransferase 1,3A,3B has been noted in various odontogenic tumors. Thus, this review aims to study the various epigenetic pathways that are altered in odontogenic tumors.
Epigenetic Mechanisms of Gene regulation. Vol. 32. 1996
Genes, genetics, and epigenetics: a correspondence. Science 2001;293(5532):1103–1105
The molecular hallmarks of epigenetic control. Nat Rev Genet 2016;17(8):487–500
Epigenetics. 2nd ed. Cold Spring Harbor Laboratory Press; 2015
Epigenetics: general characteristics and implications for oral health. Restor Dent Endod 2015;40(1):14–22
Molecular mechanisms of epigenetics. Biochemistry (Mosc) 2005;70(4):406–423
Epigenetic mechanisms in inflammation. J Dent Res 2011;90(1):9–17
DNA methylation and human disease. Nat Rev Genet 2005;6(8):597–610
DNA methylation in development and human disease. Mutat Res 2008;647(1-2):30–38, 30–38
DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer. Cancer Res 2009;69(18):7412–7421
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function. Hum Mol Genet 2008;17(5):690–709
CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature 2000;405(6785):486–489
S-adenosylmethionine: jack of all trades and master of everything? Biochem Soc Trans 2006;34(Pt 2): 330–333
DNA methylation of cancer genome. Birth Defects Res C Embryo Today 2009;87(4):335–350
DNA methylation: superior or subordinate in the epigenetic hierarchy? Genes Cancer 2011;2(6):607–617
Epigenetics: connecting environment and genotype to phenotype and disease. J Dent Res 2009;88(5):400–408
Non-coding RNAs as regulators of gene expression and epigenetics. Cardiovasc Res 2011;90(3):430–440
Epigenome effort makes its mark. Nature 2010;467:646
Epigenetics: a new frontier in dentistry. Aust Dent J 2014;59(1, Suppl 1):23–33
Epigenetics: a possible answer to the undeciphered etiopathogenesis and behavior of oral lesions. J Oral Maxillofac Pathol 2016;20(1):122–128
The influence of epigenetics in relation to oral health. Int J Dent Hyg 2014;12(1):48–54
Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Arch Oral Biol 2009;54(Suppl 1): S3–S17
Epigenetics and periodontal disease: future perspectives. Inflamm Res 2009;58(10):625–629
Epidemiology of periodontal disease. J Periodontol 2005;76:1406–1419
Genes and gene polymorphisms associated with periodontal disease. Crit Rev Oral Biol Med 2003;14(6):430–449
Effect of genetic variability on the inflammatory response to periodontal infection. J Clin Periodontol 2005;32Suppl 6: 72–86
Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals. Clin Exp Immunol 2007;148(1):119–126
Impact of inflammation on epigenetic DNA methylation—a novel risk factor for cardiovascular disease? J Intern Med 2007;261(5):488–499
Epigenetic biomarkers: a step forward for understanding periodontitis. J Periodontal Implant Sci 2013;43(3):111–120
Epigenetic regulation of TNFA expression in periodontal disease. J Periodontol 2013;84(11):1606–1616
Alteration of PTGS2 promoter methylation in chronic periodontitis. J Dent Res 2010;89(2):133–137
Interferon-gamma promoter hypomethylation and increased expression in chronic periodontitis. J Clin Periodontol 2010;37(11):953–961
Expression, polymorphism and methylation pattern of interleukin-6 in periodontal tissues. Immunobiology 2013;218(7):1012–1017
Epigenetic modulation of dental pulp stem cells: implications for regenerative endodontics. Int Endod J 2016;49(5):431–446
Human stem cell delivery for treatment of large segmental bone defects. Proceedings of the National Academy of Sciences of the USA. 2010;107:3305–3310
Histone acetylation and chromatin signature in stem cell identity and cancer. Mutat Res 2008;637(1-2):1–15
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97(25):13625–13630
Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells. Cell Stem Cell 2009;4(4):359–369
Bone. In: DiFiore's Atlas of Histology with Functional Correlations. Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008:79–98
Mesenchymal dental stem cells in regenerative dentistry. Med Oral Patol Oral Cir Bucal 2002;17(6):1062–1064
HDAC inhibitor trichostatin A promotes proliferation and odontoblast differentiation of human dental pulp stem cells. Tissue Eng Part A 2013; 19(5-6):613–624
Histone deacety-lase inhibitors epigenetically promote reparative events in primary dental pulp cells. Exp Cell Res 2013; 319(10):1534–1543
The fine tuning role of microRNARNA interaction in odontoblast differentiation and disease. Oral Dis 2015;21(2):142–148
The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR. Eur J Cancer 2003;39(13):1881–1887
Intraoperative molecular margin analysis in head and neck cancer. Arch Otolaryngol Head Neck Surg 2004;130(1):39–44
Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues. Oral Oncol 2004;40(2):145–153
Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. J Cancer Res Clin Oncol 2006;132(11):735–743
Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res 2002;62(18):5295–5300
High frequency of hypermethylation of p14, p15 and p16 in oral pre-cancerous lesions associated with betel-quid chewing in Sri Lanka. J Oral Pathol Med 2008;37(8):475–479
Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis. Clin Cancer Res 2004;10(5):1733–1742
Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol 2006;7(1):77–82
Value of HIF-1á as an independent prognostic indicator in oral squamous cell carcinoma. Expert Rev Mol Diagn 2011;11(2):145–147
