Introduction Luting cements are susceptible to attack by moisture during the initial setting period that can result in an increased solubility. The aim of this in vitro study was to evaluate the solubility of different permanent and temporary dental luting cements in artificial saliva of different pH values at different time intervals. Materials and Methods Eight commercial luting cements were used. Out of which five were permanent cements (Rely X lute2, zinc phosphate cement, zinc polycarboxylate cement, Rely X U-200, GC GIC) and three temporary cements (ZOE, Oratemp NE, Temposil). A total of 200 samples were made into 25 specimens of each cement (five samples for each study solution group). The samples were made of dimension 20 mm × 1.5 mm in the metal mold. Once the cements were set, they were removed and after 3 minutes of removal they were placed in the incubator at 37°C ± 1 for 1 hour. Specimens of each cement type were separated into five groups for evaluation and comparison in distilled water and artificial saliva with four different pH values (pH 3, pH 5, pH 7, and pH 9). Percentage of solubility was calculated as 100% times weight loss divided by initial weight of the specimen. Results When all permanent cements were tested the result showed that Rely X U-200 showed least dissolution even after 28 days, followed by Rely X lute-2, then Glass ionomer cement then zinc polycarboxylate cement and then zinc phosphate cement which gave maximum dissolution. Conclusion When all temporary cements were tested the result showed that Temposil showed least dissolution even after 28 days, followed by OraTemp NE, compared with zinc oxide eugenol which gave maximum dissolution.