Recent studies suggest that Stem Cells being used for a number of regenerative diseases. Stem cells can self-renew and produce different cell types, thus providing new strategies to regenerate missing tissues and treat diseases. In the field of dentistry, adult mesenchymal stem/stromal cells (MSCs) have been identified in several oral tissues, which suggests that the oral tissues are a rich source of stem cells, and oral stem and mucosal cells are expected to provide an ideal source for genetically reprogrammed cells such as induced pluripotent stem (IPS) cells. Furthermore, oral tissues are expected to be not only a source but also a therapeutic target for stem cells, as stem cell and tissue engineering therapies in dentistry continue to attract increasing clinical interest. With appropriate biochemical signals stem cells can be transformed into desirable cells. The idea behind this article is to shortly review the obtained literature on stem cell with respect to their properties, types and advantages of dental stem cells. Emphasis has been given to the possibilities of stem cell therapy including regeneration of tooth and craniofacial defects.
Origin of stem cells in organogenesis. Science 2008;322: 1498–501.
Tissue engineering. Science 1993;260:920–6.
Tissue engineering's impact on dentistry. J Dent Educ 2001;65:456–62.
Toward a new era in prosthodontic medicine. J Prosthodont Res 2012;56:1–2.
Periodontal diseases and oral bone loss. In: Rosen CJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 7th ed., Washington, DC: American Society for Bone and Mineral Research; 2008. p. 510–3.
Reduction of residual ridges: a major oral disease entity. J Prosthet Dent 1971;26:266–79.
Ridge preservation: what is it and when should it be considered. Aust Dent J 2008;53:11–21.
A small-molecule approach to bone regenerative medicine in dentistry. J Oral Biosci 2010;52:107–18.
IPS cells in dentistry. Clin Calcium 2012;22:67–73.
Current and future periodontal tissue engineering. Periodontology 2000 2011;56:166–87.
A novel approach to periodontal tissue regeneration with mesenchymal stem cells and platelet-rich plasma using tissue engineering technology: a clinical case report. Int J Periodontics Restorative Dent 2006;26:363–9.
Injectable bone applied for ridge augmentation and dental implant placement: human progress study. Implant Dent 2008;17:82–90.
Injectable tissue-engineered bone using autogenous bone marrow-derived stromal cells for maxillary sinus augmentation: clinical application report from a 2–6-year follow-up. Tissue Eng Part A 2008;14:1699–707.
Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration. Oral Dis 2011;17:445–448.
Successful myoblast transplantation in rat tongue reconstruction. Head Neck 2006;28:517–24.
Craniofacial muscle engineering using a 3-dimensional phosphate glass fibre construct. Biomaterials 2005; 26:1497–505.
Osteochondral interface regeneration of rabbit mandibular condyle with bioactive signal gradients. J Oral Maxillofac Surg 2011;69:50–7.
Stem cells: Potency, plasticity and public perception. J Anat 2002;200:277-82.
The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-36.
The first half-century of nuclear transplantation. Proc Natl Acad Sci USA 2003;100:8048-52.
Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-7.
In vitro differentiation of embryonic stem cells. Curr Opin Cell Biol 1995;7:862-9.
Stem cells, classifications, controversies and clinical applications. Vet Surg 2005;34:415-23.
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-76.
Multilineage cells from human adipose tissue: Implications for cell- based therapies. Tissue Eng 2001;7:211-28.
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 2000;97:13625-30.
SHED: Stem cells from human exfoliateddeciduous teeth. Proc Natl Acad Sci USA 2003;100:5807-5810.
Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet 2004; 364:149-55.
Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: A pilot study. J Endod 2008;34:166-71.
Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 2005;24:155-65.
Mesenchymal stem cells derived from dental tissues vs. those from other sources: Their biology and role in regenerative medicine. J Dent Res 2009;88:792-806.
Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur Cell Mater 2009;18:75-83.
Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: Case report. J Craniomaxillofac Surg 2004;32:370-3.
Engineered adipose tissue from human mesenchymal stem cells maintains predefined shape and dimension: Implications in soft tissue augmentation and reconstruction. Tissue Eng 2005;11:556-66.
Osteogenic differentiation influences stem cell migration out of scaffold-free microspheres. Tissue Eng Part A 2010;16:759-66.
Stem cells from human exfoliated deciduous teeth (SHED) enhance wound healing and the possibility of novel cell therapy. Cytotherapy 2011;13:598-605.
Toothforming potential in embryonic and postnatal tooth bud cells. Med Mol Morphol 2008;41:183-92.
Tooth regeneration: Implications for the use of bioengineered organs in first-wave organ replacement. Hum Cell 2007;20:63-70.
Signalling networks regulating dental development. Mech Dev 1997;67:111-23.
Whole-tooth regeneration: It takes a village of scientists, clinicians, and patients. J Dent Educ 2008;72:903-11.
Bioengineered teeth from cultured rat tooth bud cells. J Dent Res 2004;83:523-8.
Histological and Immunohistochemical studies of tissue engineered odontogenesis. Arch Histol Cytol 2005;68:89-101.
Craniofacial tissue engineering by stem cells. J Dent Res 2006;85(11):966–79.
Comparison of human mesenchymal stem cells derived from dental pulp, bone marrow, adipose tissue, and umbilical cord tissue by gene expression. J Endod 2009;35:1536-42.
Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143–7.
SHED: Stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci USA 2003;100:5807–12.
Parallels between tooth development and repair: conserved molecular mechanisms following carious and dental injury. J Dent Res 2004;83:896–902.
Mesenchymal stem cell mediated functional tooth regeneration in swine. PLoS ONE 2006;1:79.
Tooth regeneration from newly established cell lines from a molar tooth germ epithelium. Biochem Biophys Res Commun 2007; 355:758–63.
Regulation of epithelial stem cells in tooth regeneration. CR Biol 2007;330:561–4.