Oral submucous fibrosis (OSMF) is a well-recognized, potentially malignant condition of the oral cavity that can affect any part of the oral mucosa. It is strongly associated with a risk of oral cancer, although the biology underlying this association is still unresolved. The purpose of this paper is to show the histopathological prototypical illustration of OSMF turning into oral squamous cell carcinoma.
Pillai R, Balaram P. Pathogenesis of oral submucous fibrosis: relationship to risk factors associated with oral cancer. Cancer 1992;69:2011–20
Hammer JE, Mehta FS; eds. Tobacco related oral mucosal lesions and conditions in India. Mumbai: Basic Dental Research Unit, Tata Institute of Fundamental Research; 1993.
Mithani SK, Mydlarz WK, Grumbine FL, Smith IM, Califano JA. Molecular genetics of premalignant oral lesions. Oral Dis 2007; 13:126-33.
Murti PR, Bhonsle RB, Pindborg JJ, Daftary DK, Gupta PC, Metha FS. Malignant transformation rate in oral sub mucous fibrosis over a 17-year period. Community Dent Oral Epidemiol 1985; 13:340-1.
Gupta PC, Hebert JR, Bhonsle RB, Sinor PN, Mehta H, Mehta FS. Dietary factors in oral leukoplakia and submucous fibrosis in a population-based case control study in Gujarat, India. Oral Dis 1998;4:200–6.
Borle RM, Nimonkar PV. Extended nasolabial flaps in the management of oral submucous fibrosis. British Journal of Oral and Maxillofacial Surgery. 2009;47:382–5.
Paymaster JC. Cancer of buccal mucosa- clinical study of 650 cases in Indian Patients. Cancer 1956; 9:431-5.
Ray JG, Ranganathan K, Chattopadhaya A. Malignant transformation of oral submucous fibrosis: overview of histopathological aspects. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;122(2):200-9.
