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VOLUME 12 , ISSUE 1 ( January-April, 2024 ) > List of Articles


Managing Periodontitis with Host Modulation Therapy: Current Concept and Future Perspective

Nidhi Chandel, Ajay Mahajan, Kanwarjit S Asi, Monika S Walhe

Keywords : Host modulating agents, Host modulation, Pathogenesis of periodontitis, Periodontology

Citation Information : Chandel N, Mahajan A, Asi KS, Walhe MS. Managing Periodontitis with Host Modulation Therapy: Current Concept and Future Perspective. 2024; 12 (1):29-33.

DOI: 10.5005/djas-11014-0035

License: CC BY-NC-ND 4.0

Published Online: 30-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


As our basic knowledge of the etiopathogenesis of periodontitis has improved over the past years, it has become evident that the periodontal disease is multifactorial disease caused by the bacteria which establishes the immune reaction in the host. This initiation of the host response leads to destruction of the surrounding periodontium which ultimately results in tooth loss. An ever-increasing research in the field of pathogenesis of periodontitis has revealed that the initial breakdown in chronic inflammatory periodontal disease often involves a failure of resolution pathways in order to restore host's homeostasis. The practice of modulating the host response to control periodontal disease has been employed for many years not only for the periodontal disease but also for various medical conditions. As a result, the goal of this review is to provide an overview of existing findings on host modulation therapies (HMTs). In addition, to describe some of the recent advances made over the years in the field of HMTs and to determine some pertinent conclusions about its involvement in disease development and its use in clinical therapy. This will provide a chance for more detailed investigation in this particular field. As a result, the goal of this review is to describe the current findings available in the literature on HMT.

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