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VOLUME 12 , ISSUE 1 ( January-April, 2024 ) > List of Articles


Evaluation of Casein Phosphopeptide–Amorphous Calcium Phosphate Effect on the Bond Strength of Self-etch Adhesives to Dentin: A Systematic Review

Suyash Joshi, Nupur Ninawe, Hemraj Badhe, Shivani Bhadule, Karthika Krishnakumar, Nilam V Honaje

Keywords : Dental bonding, Dental etching, Systematic review

Citation Information : Joshi S, Ninawe N, Badhe H, Bhadule S, Krishnakumar K, Honaje NV. Evaluation of Casein Phosphopeptide–Amorphous Calcium Phosphate Effect on the Bond Strength of Self-etch Adhesives to Dentin: A Systematic Review. 2024; 12 (1):55-64.

DOI: 10.5005/djas-11014-0038

License: CC BY-NC-ND 4.0

Published Online: 30-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) is used as a remineralizing agent, ultimately reducing dental caries. The systematic review was performed as a review on the evaluation of CPP–ACP effect on the bond strength of self-etch adhesives to dentin. Medline (via PubMed) and Google Scholar were among the databases that were searched. Articles written exclusively in English and released up until 30 November 2021, were included. Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) criteria were followed in the conduct of this research. There were 479 published studies found in the search results. Thirteen studies were chosen following full-text analysis and the elimination of duplicate studies. Overall, the outcomes showed that CPP–ACP has positive impacts on the bond strength of self-etch adhesive to dentin. The search keywords were “CPP–ACP (Title/Abstract)” OR “tooth mousse (Title/Abstract)” OR “MI-paste (Title/Abstract)” AND “bond strength (Title/Abstract)” OR “tensile bond strength (Title/Abstract)” OR “microtensile bond strength (Title/Abstract)” OR “shear bond strength (Title/Abstract).” The bond-strength test is used to determine the ability of self-etch adhesives to remain in contact with the application of CPP–ACP as a remineralizing agent on the dentin while under stress. The impact of CPP–ACP application on dentin's bond strength to self-etch adhesives cannot be concluded due to the significant degree of variation among the included research.

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