Oral mucosa is one of the most common sites for reactive lesions as it is exposed to various internal and external stimuli. Pyogenic granuloma (PG) and peripheral ossifying fibroma (POF) are the most common reactive lesions associated with gingiva. Both lesions have similar clinical features and can be differentiated based on histopathology only. Pyogenic granuloma is a type of benign swelling and type of inflammatory hyperplasia that results in response to chronic irritation, trauma, and fluctuating hormones. Microscopically, ossification is a feature of POF and it is not seen in PG. This article aims to discuss the histopathology of PG in a young 18-year-old female patient, in which areas of ossification were seen that are not commonly encountered in this lesion.
Elanagai R, Veeravarmal V, Nirmal RM. Osteopontin expression in reactive lesions of gingiva. J Appl Oral Sci 2015;23:26–32. DOI: 10.1590/1678-775720140122.
Jafarzadeh H, Sanatkhani M, Mohtasham N. Oral pyogenic granuloma: A review. J Oral Sci 2006;48(4):167–175. DOI: 10.2334/josnusd. 48.167.
Effiom OA, Adeyemo WL, Soyele OO. Focal reactive lesions of the gingiva: An analysis of 314 cases at a tertiary health institution in Nigeria. Nigerian Med J 2011;52(1):35–40. PMID: 21968923.
Ganesan A, Kumar NG, Azariah E, et al. Oral pyogenic granuloma: A case report and a comprehensive review. SRM J Res Den Sci 2015;6(4):257–260. DOI: 10.4103/0976-433X.170284.
Godinho GV, Silva CA, Noronha BR, et al. Peripheral ossifying fibroma evolved from pyogenic granuloma. Cureus 2022;14(1):e20904. DOI: 10.7759/cureus.20904.
Dave A, Arora M, Saluja P, et al. An insight into pyogenic granuloma with ossification: Exploring a unique association. J Clin Diagn Res 2021;15(9):ZD01–ZD03. DOI: 10.7860/JCDR/2021/50298.15337.
Prior JC. Progesterone as a bone-trophic hormone. Endocrine Rev 1990;11(2):386–398. DOI: 10.7759/cureus.20904.
Kim ES, Kim KJ, Chang SE, et al. Metaplastic ossification in a cutaneous pyogenic granuloma: A case report. J Dermatol 2004;31(4):326–329. DOI: 10.1111/j.1346-8138.2004.tb00679.x.
Dermawan JK, Kilpatrick SE. Ossifying pyogenic granuloma: A rare variant usually not recognized. J Cutaneous Pathol 2021;48(7): 954–957. DOI: 10.1111/cup.14007.
Narwal A, Bala S. Osteopontin expression and clinicopathologic correlation of oral hyperplastic reactive lesions: An institutional 6-year retrospective study. J Oral Maxillofac Pathol 2017;21(3): 382–386. DOI: 10.4103/jomfp.JOMFP_231_15.
Sridhar R, Wanjari S, Kanteshwari IK. Interrelationship between pyogenic granuloma and peripheral ossifying fibroma: A case report. J Dent Hyg 2012;86(3):179–184. PMID: 22947840.
Al Eid RA. Peripheral ossifying fibroma mimicking pyogenic granuloma: A case report and review of literature. J Surg 2020;6(1):1–4. DOI: 10.16966/2470-0991.204.
