The malignant tumors develop when tumor cells overcome the cell–cell adhesion and invade the surrounding tissue. The epithelium consists of E-cadherin as the main adhesion molecule, which is mainly implicated in the carcinogenesis as it is frequently lost in the human epithelial tumors. Epithelial–mesenchymal transition (EMT) and its reverse mesenchymal–epithelial transition (MET) have been suggested to play crucial roles in metastatic dissemination of carcinomas. E-cadherin loss may promote invasion, and re-expression may facilitate cell survival within metastatic deposits. The mechanisms underlying such plasticity are unclear. Here, we summarize the role of cadherins in EMT- and MET-associated tumorigenesis by accumulating the experimental evidences that directly supports it.

Periodontally accelerated osteogenic orthodontics (PAOO), also known as Wilckodontics, is a clinical procedure that combines corticotomy (a surgical technique in which the bone is cut, perforated, or mechanically altered), particulate bone grafting, and orthodontic force application. By this procedure, the teeth can be made to move through the bone rapidly by means of harnessing and stimulating the innate potential of the bone and utilizing tissue engineering principles. Once the tooth movement gets completed, bone rebuilds around the tooth, thereby reducing the time of orthodontic treatment from years to months. This article aims to present a comprehensive review about PAOO or Wilckodontics.

The purpose of this article is to illustrate the fabrication process of presurgical nasoalveolar molding (PNAM) prosthesis. Growth of alveolar ridges, lips, and nose is initiated and directed by PNAM prosthesis at the presurgical time. Presurgical nasoalveolar molding helps reduce the future complications of lip and nasal surgery. Because of use of this appliance, there are minimum tension and minimum scar formation due to repair of soft tissue and cartilaginous deformity.

Objective To assess the adequacy of various light-curing units to polymerize the posterior composite resin. Materials and Methods Specimens were prepared by placing a single increment of posterior composite resin in split cylindrical metallic mold of dimension (6.0 mm in diameter and 5 mm in depth). Polymerization was done by utilizing one quartz-tungsten-halogen and three light-emitting diode light-curing units of different powers. The specimens of composite resin were then mounted on metallic molds utilizing autopolymerizing acrylic resin. After polishing, the complete setting of composite resin material was analyzed using Vickers hardness test. Results Showed in each group, hardness reduced as we moved from upper to lower surface of composite resin. Furthermore, hardness increased as intensity of light was increased. The maximum hardness was detected when light-emitting diode light-curing unit having intensity of 1,250 mW/cm² was utilized and least hardness was detected when halogen lamp having intensity 418 mW/cm² was utilized and results were found to be highly significant (p < 0.01). Conclusion It was concluded that increased top and bottom hardness can be accomplished by utilizing the light-curing unit of high intensity.

Objectives The aim of this study was to compare canal aberrations and transportation of Endowave and K3 rotary nickel-titanium files in simulated canals with 40-degree curvature. Materials and Methods Twenty simulated canals with 40-degree curvature were divided into two groups (each of 10). In one group, canals were instrumented with Endowave and in the other group with K3. Both systems were used in crown-down manner, and canals were prepared till apical size # 25/0.06 taper. The pre- and post-instrumentation radiographic scanned images were superimposed on each other using software movements and viewed for canal aberrations and transportation. Results are statistically analyzed using Student's t-test. Results In the canals prepared with Endowave files, one (10%) ledge was created whereas in the canals prepared with K3 files, one (10%) apical zip and elbow, one (10%) ledge, and two (20%) perforations were created. When two groups were compared, results were statistically insignificant (p > 0.05) for the amount of resin removed from inner and outer aspect of the canal. Conclusions Endowave files revealed better results in terms of the canal aberrations compared to K3 files. The direction of transportation was generally toward the outer aspect with both files.

Objective The aim of this study was to investigate the incidence of cracks in root dentin after root canal preparation with SmartTrack files, ProTaper Next files, and HyFlex CM files. Materials and Methods Sixty extracted single-rooted human mandibular premolars with one canal were used for the study. Fifteen teeth were left unprepared and served as control; another 15 were instrumented with SmartTrack files up to 30/0.06, and the remaining 30 were shaped with ProTaper Next till X3 and HyFlex CM files up to 30/0.04. After root canal preparation, all the roots were sectioned perpendicular to the long axis at 2, 4, and 6 mm from the apex, and the sections were then observed under a stereomicroscope. The absence or presence of cracks was recorded. Results No cracks were observed in the control group. There was presence of cracks at all the levels in all the experimental groups. There was a significant difference in crack formation when the groups were compared whereas this difference was not significant when the levels were compared (p > 0.05). In the SmartTrack group, there was crack in 73% samples whereas in HyFlex CM and ProTaper Next, the number of samples with cracks was 27% and 53%, respectively. In the apical region, the number of samples that shows cracks was 29% whereas the number of cracks in the middle and coronal regions was 20%. Conclusion Within the limitations of this study, root canal preparation with rotary nickel-titanium (Ni-Ti) instruments can cause crack formation in root canal dentin. The ProTaper Next and HyFlex instruments have a tendency to cause fewer dentinal cracks compared with the SmartTrack instruments.

Aim The aim of this study was to compare the canal transportation and canal centric ability of One Shape (Micro Mega, Besançon, France) and Mani Silk (Mani Utsunomiya, Tochigi, Japan) nickel-titanium (NiTi) rotary files in curved canals with the help of cone beam computed tomography (CBCT). Materials and Methods Total 40 mesiobuccal canals of maxillary molars with an angle of curvature ranging between 25 and 45 degrees were divided according to the instrument used in canal preparation into two groups 20 samples each: One Shape (group 1) and Mani Silk (group 2). Pre- and post-instrumentation scans were performed using CBCT (Carestream CS 9300 scanner) to evaluate the transportation and centric ability at apical, middle, and coronal levels using unpaired Student's t-test. Results Mani Silk file showed significantly less canal transportation and better canal centric ability compared to One Shape system. Conclusion Mani Silk file maintained original canal curvature better than One Shape NiTi rotary file.

Introduction The knowledge of the nature and magnitude of growth and development of human face is important for sound diagnosis and treatment of dentofacial disharmonies. The depth of antegonial notch and morphology of mandible are important indicators of growth pattern. Objective The purpose of this study was to evaluate the antegonial notch depth, mandibular symphysis morphology, and symphysis inclination in various facial types categorized into the normo-, hypo-, and hyperdivergent groups using various parameters. Materials and Methods Pretreatment lateral cephalograms of 45 adult patients with age group between 16 and 30 years were taken. The antegonial notch depth, symphysis height, symphysis depth, ratio (height of symphysis/depth of symphysis), angulation of symphysis, and inclination of symphysis to mandibular plane were analyzed statistically. Result It was found that the mandible with the hyperdivergent growth pattern was associated with an increased antegonial notch depth, increased symphysis height, reduced symphysis depth, large ratio, small symphysis angle, and large inclination angle of the symphysis. Conclusion The results for the antegonial notch depth, symphysis height, symphysis depth, and ratio of symphysis height to symphysis depth were statistically significant whereas the angulation of the symphysis and inclination of the symphysis did not show statistically significant results.

Introduction The impact of third molars in occurrence of secondary mandibular incisor crowding has been a disputable subject and is reviewed in the dental literature for many years. The relationships between lower third molar angulation, eruption level, and eruption space to lower anterior crowding are not completely understood. Aim To evaluate the relation between the third molar angulations, eruption space, eruption level, and mandibular anterior crowding. Materials and Methods Pretreatment plaster study models (mandibular dental arches) and orthopantomograph of 40 individuals, aged between 12 and 22 years, were part of the study. The whole sample was divided into two groups based on the Little's index of irregularity: group I—control group (n = 20) composed of patients with index 0 to 3 mm, and group II—study group (n = 20) composed of patients with index > 3 mm. Calculations were made for the third molar eruption depth, eruption space, and angulation. Statistical Analysis Mean values were compared for selected dimensions between the control and study groups with Student's t-test. Results Statistically significant differences for Ganss ratio in right side between the control and study groups with a p-value of 0.049 were observed. Statistically insignificant difference was seen between the control and study groups for other parameters. Eruption level B was found for maximum molars in the study group, 95% on right and 85% on left side. Conclusion It was inferred that no strong relation exists between the third molar eruption level, space, and angulations to mandibular anterior crowding.

Finite element analysis is a technique for obtaining a solution to a complex mechanical problem by dividing the problem domain into a collection of much smaller and simpler domains (elements) in which the field variables can be interpolated with the use of shape functions. An overall approximated solution to the original problem is determined based on variational principles. Finite element analysis can provide a nondestructive system for quantifying stresses generated at the various interfaces of similar or dissimilar material. The finite element method also allows the study of the internal state of stress of components as well as stress patterns in two or more dissimilar materials adjacent to each other without affecting their independent behavior. This method is therefore ideally suitable for the biomechanical analysis of orthopedic, cardiovascular, and dental structures. In this study, implants of different length were numerically analyzed using bone-implant models developed from computed tomography-generated images of the mandible with osseointegrated implants. The impact of various lengths on stress distribution was examined using implants with a length of 8, 10, and 13 mm in mandibular first molar region under axial load of 100 N and buccolingual load of 50 N. All materials were assumed to be linearly elastic and isotropic. The Statistical Package for the Social Sciences software package was used for statistical analysis. Maximum von Mises stresses were located around the implant neck. It was demonstrated that there was statistically nonsignificant decrease in von Mises stress as the implant length increased. Within the limitations of this study, there was statistically nonsignificant decrease in von Mises stress as the implant length increased.

Statement of Problem The adhesion of impression material to impression tray is very important. Tray adhesive plays a major role in making accurate impression. Although manufactures recommend the use of particular tray adhesives, comparison of their affective adhesiveness has not been reported. The effect of use of tray adhesives on dimensional accuracy of dies has not been established. Purpose The aim of this study was to compare the dimensional accuracy of dies using different tray adhesives at different time intervals. Materials and Methods First part of study comprised 120 samples in six groups with 20 samples in each group. First group comprised samples with no tray adhesive, and in other five groups, different types of tray adhesives were applied. The dies obtained were evaluated for upper diameter, lower diameter, and occlusogingival height. In the second part, there were a total of 125 samples in five groups with 25 samples in each group. Five different types of tray adhesive were applied for five different time intervals 5, 10, 15, 20, and 25 minutes, respectively. The specimens were tested in tensile mode for its debonding force at a crosshead speed of 5 mm/min, until separation failure occurred. Results Significant difference was seen for upper and lower diameters when compared with the group without any tray adhesive. The maximum bond strength was found in the group in which tray adhesive was applied for 20 minutes.

Introduction The facial growth pattern differs from individual to individual, and the variations in it are quite high. The assessment of relationship of dental arch dimensions with the facial growth pattern is essential for proper diagnosis and treatment planning. Aim The purpose of this study was to evaluate and compare the dental and alveolar arch widths in patients with varying facial growth patterns in Distt. Solan population. Materials and Methods Pretreatment lateral cephalograms and dental study models of 45 patients with age group between 16 and 30 years were included in the study. Patients were divided into three groups: group I (normodivergent), group II (hypodivergent), and group III (hyperdivergent) on the basis of y-axis, Jarabak ratio, and SN-MP (Sella-Nasion–mandibular plane) angle. Interpremolar and intermolar dental and alveolar arch widths were measured and compared for all the three groups. Results The results showed that the dental and alveolar arch widths were increased in hypodivergent patients and decreased in hyperdivergent patients, which was not statistically significant. Conclusion It was concluded that the dental and alveolar arch dimensions increased as the facial pattern became horizontal.

Tandem appliance is preferred over face mask mainly because of compliance reasons. In the given case report, clinicians have used tandem appliance for correcting skeletal class III malocclusion patient in later stage of growth. Operators utilized residual growth. Facial harmony was achieved by gaining positive overjet. Adolescent class III malocclusion is challenging to treat. Occurrence of class III malocclusion is just 5% in India. If patient reports in growing stage, clinicians get many relevant treatment options. Lack of knowledge about growth modulation therapy causes loss of growing stage of patients. This situation reduces available treatment modalities. Here is a case of female patient with class III malocclusion who is near completion of her growth; maxillary growth was stimulated in forward direction taking anchorage from overgrown mandible with the help of tandem appliance.

A hybrid denture is fabricated over a metal framework that is retained by screws into the implants. The anterior part of a hybrid denture is fixed on implants and the posterior part of the denture is cantilevered. This case report presents the fabrication of a maxillary implant retained hybrid prosthesis. Four implants were placed in the maxillary arch. Framework was waxed, castable abutments were used, after-casting denture teeth were waxed to the hybrid framework, and a final try-in was done to verify and correct maxillomandibular relations before processing. The prosthesis was inserted after verifying fit of the framework.

Ankyloglossia is a development abnormality in which a child cannot move his/her tongue ahead of mandibular incisors. It can lead to skeletal as well as dentoalveolar changes such as prognathic mandible, posterior open bite, retrognathic maxilla, and midline diastema in lower incisors. Laser frenectomy was performed in this case to relieve the tongue tie. Healing was uneventful.

The patient with complete edentulous maxillary arch and partially edentulous mandibular arch poses certain complication in the form of syndrome which was described by Kelly in 1972. There is flabby tissue in the anterior maxilla and posterior occlusal plane slope-down. There is supraeruption of lower anterior teeth, fibrous growth of tuberosity area, resorption of bone in the posterior mandibular ridges, and loss of vertical dimension of occlusion. The treatment varies from patient to patient to develop this syndrome and also varies from condition of the remaining teeth. Best treatment option is to use dental implants, but conventional prostheses are used in complex cases. This clinical report presents the prosthetic rehabilitation of a patient exhibiting combination syndrome.

A removable dental prosthesis that covers and rests on two or more remaining natural teeth, the roots of natural teeth, and/or dental implants is known as overdenture. This leads to less resorption of residual alveolar ridges. Restoration and modified teeth coronally can also be used as multiple abutments. In most cases, abutments are treated endodontically. In most patients with complete dentures, mandibular denture is difficult to adapt, and there is loss of retention because of less surface area. This case report represents prosthetic rehabilitation of a mandibular edentulous patient with cast coping with short dowels supported overdenture.