Fixation is considered as physiochemical process where cells or tissues are fixed chemically. Fixatives perform various functions such as prevention of autolysis and tissue putrefaction. Various fixative agents include formaldehyde, glutaraldehyde, osmium tetroxide, glyoxal, picric acid, and so on. A detailed search on PubMed, Google scholar, and Scopus database showed very few articles on “fixation” and “fixative.” Keeping this fact in mind, a comprehensive review on fixation and fixatives was prepared. The main aim of this review is to make pathologists and laboratory technicians familiar with the basic aspects and different types of fixatives.

The accurate examination of oral cavity may acknowledge findings that demonstrate the presence of underlying systemic, which helps in earlier diagnosis as well as treatment. The oral tissues are accountable to damage as a disease consequence that primarily affects other body systems. Various systemic diseases show oral manifestation. Some of these oral conditions include oral ulcers, caries, dry mouth, gingival bleeding, and gingival hypertrophy. This review article is prepared to make general physicians as well as dentist aware about systemic disorders or conditions that show dental or oral manifestation.

Introduction Pulpectomy helps in preserving a pulpally involved primary tooth by eliminating bacteria and their products and ensures hermetic seal of the root canals, so that the primary teeth can complete their function until normal exfoliation. For the success of endodontic treatment in primary teeth, the resorption of obturating material plays a vital role. The materials used for obturation in this study included zinc oxide propolis (ZOP) as a new paste, Endoflas, Metapex, and zinc oxide eugenol (ZOE). Objective To evaluate the success rate of pulpectomy of primary molars using four different root canal filling materials: ZOP as a new paste, Endoflas, Metapex, and ZOE. Materials and Methods A total of 48 primary molars were divided into four equal groups of 12 molars according to the type of root canal filling paste, that is, ZOE, Endoflas, ZOP, and Metapex. Results When Tukey's test was applied, out of the four materials, ZOP was the most significant material as its p-value was < 0.05, whereas other materials showed nonsignificant results as their p-value was > 0.05. Conclusion Among the four groups, ZOP showed greater clinical success and its resorbability was similar to that of root.

Objective The goal of root canal therapy is thorough disinfection and obturation of the root canal system in all its dimensions. Success of endodontic treatment is highly related to the elimination of postendodontic pain, tenderness, and swelling. Single-visit endodontic therapy has several advantages such as increased patient acceptance, less overhead costs, and only single time local anesthesia administration is required. Multiple-visit endodontic (MVE) treatment allows the clinician to determine the effect of the therapy on the inflamed tissues and shorter appointments. This in vivo study was undertaken to compare the postoperative incidence of pain, swelling, tenderness, and radiographic evaluation of periapical pathology following single- versus multiple-visit endodontic therapy in vital as well as nonvital teeth. Materials and Methods A total of 60 subjects in the age group of 15 to 50 years were selected for the study. The patients were divided into four groups: • Group 1 (n = 15): Single-visit endodontic (SVE) therapy with vital pulp involvement without periapical rarefaction. • Group 2 (n = 15): SVE therapy of asymptomatic pulpless teeth with periapical rarefaction as observed in radiographic evaluation. • Group 3 (n = 15): MVE of vital pulp involvement without periapical rarefactions. • Group 4 (n = 15): MVE therapy of asymptomatic pulpless teeth with periapical rarefaction as observed radiographically. Access cavity was prepared, working length was taken. Biomechanical preparation was done with Protaper universal rotary file system and obturation was done immediately in single-visit cases. In multivisit cases, Ca (OH)₂ is placed as an intracanal medicament and obturation was done with the help of AH plus sealer and gutta-percha. Postobturation pain levels, swelling, and tenderness on percussion were assessed till 6 weeks. The radiographic parameter was studied till 18 months follow-up. Results Among the different experimental groups, maximum patients in MVE without periapical rarefaction showed no pain according to visual analog scale (VAS) scale, swelling, and tenderness and in SVE with periapical rarefaction showed maximum number of patients reported with pain, tenderness, and swelling. At 4 and 6 weeks postoperatively, patients in all the groups exhibited no pain, swelling, and tenderness to percussion. As periapical rarefaction, healing of periapical lesion was evident in all the patients after 18 months.

Introduction The position of the incisors is considered as a key landmark in treatment planning to provide the patient with the most attractive and well-balanced smile. It is important to quantify the relationship between anteroposterior position of incisors to overlying soft tissue structures. Aim The purpose of this study was to evaluate cephalometric changes on the soft tissue profile of the adult patients after first premolar extraction. Materials and Methods The study included pretreatment and posttreatment lateral cephalograms of 24 adult patients (Class II div 1 malocclusion and Class I bimaxillary protrusion) treated with preadjusted edgewise appliance following first premolar extractions. Seven angular and twelve linear soft tissue parameters were evaluated. Six hard tissue parameters were evaluated. Results All the linear and angular measurements pertaining to soft tissue and hard tissue showed significant changes. When posttreatment values were compared with pretreatment values, certain parameters (nasolabial angle, Z angle, UL and LL length, and UL strain) were found to be increased, whereas other parameters showed decrease in their posttreatment values. The tissue alteration showed statistically significant increase in nasolabial angle, Z angle, and decrease in soft tissue profile and interlabial gap. Conclusion Facial profile improvement can be enhanced by dentoalveolar and soft tissue retraction following premolar extraction.

Introduction The aim of modern cephalometrics is to evaluate the relationship of skeletal and dental functional units of the face and to implement treatment to establish the position of the units horizontally and vertically. Establishing a correct occlusal vertical dimension is considered one of the most important aspects of facial esthetics for patients in need of orthodontic treatment. Aim The aim of this study is to evaluate the vertical dimension of occlusion in varying dental malocclusions in Solan population. Materials and Methods The sample consisted of pretreatment lateral cephalograms of 100 patients (50 Class I and 50 Class II div 1), aged 15 to 30 years; six angular and one linear parameters were measured to determine the vertical dimension of occlusion. Results All the parameters (Frankfort-mandibular plane angle [FMA], Occl/Frankfort horizontal plane [FHA], angle of Y-axis, Occl/SN, GoGn/SN, and ANS-Me) were found to be decreased in Class I than in Class II div 1 malocclusion except (ANS-Xi-Pm). All the parameters were found to be statistically significant (p < 0.05) when compared between groups. When cephalometric norms of the present study were compared with Moroccan population, all parameters (ANS-Xi-Ptm, FMA, Occl/FH, Occl/SN, GoGn/SN, and ANS-Me) were found to be decreased in Solan population except angle of Y-axis. All the parameters were clinically significant (p < 0.05) except ANS-Xi-Pm and FMA that were found to be clinically nonsignificant (p > 0.05). Conclusion Solan population has distinct cephalometric characteristics, which should be used as the reference in future orthodontic treatments.

Introduction An attractive or pleasing smile enhances the acceptance of an individual in the society by improving interpersonal relationships. In this new era of social media, people are more concerned about their smile; hence, smile esthetics has become the primary objective of orthodontic treatment. It is seen that various smile parameters change with age and gender. Aim The aim of the study was to evaluate various smile parameters in nongrowing patients using photographic analysis. Materials and Methods The sample comprised photographs of 50 subjects (8 males, 42 females) taken in natural head position and then divided into two age groups: Group I (25 subjects, aged 18–20 years) and Group II (25 subjects, aged 23–29 years). The various parameters were analyzed using Adobe Photoshop software (version CS 6; Adobe System Inc., California, United States): upper lip and lower lip lengths during rest and smiling, smile index, buccal corridor, upper and lower lip thickness, interlabial gap, incisal display, widest visible maxillary display, and intercommissural width. Results The results showed that lower lip length at rest and smiling, interlabial gap, incisal display, inner commissure width, and widest visible maxillary display were increased, whereas upper lip length both at rest and smiling, upper and lower lip thickness, outer commissure width, smile index, and buccal corridor were decreased with age. Statistically significant sex-related differences were found in upper lip length at rest and lower lip length both at rest and smiling. Conclusion Orthodontic treatment must incorporate various esthetic elements of smile to achieve desirable results.

Giant cell granulomas (GCGs) of the jaws are non-neoplastic lesions that arise either peripherally in periodontal ligament, mucoperiosteum, or centrally in the bone. Histologically, both peripheral and central giant cell granuloma are characterized by the presence of numerous multinucleated giant cells in a prominent fibrous stroma. Peripheral giant cell granuloma is an infrequent reactive, exophytic lesion of the oral cavity, also known as giant-cell epulis, osteoclastoma, giant cell reparative granuloma, or giant cell hyperplasia. It is the most common giant cell lesion of the jaws and originates from the connective tissue of the periosteum or from the periodontal membrane, in response to local irritation or chronic trauma. The lesion develops mostly in adults, commonly in the lower jaw, with slight female predilection although is uncommon in children. Clinically, it shows resemblance to pyogenic granuloma, peripheral ossifying fibroma, and many other peripheral lesions seen in the oral cavity, but in our case it resembled a squamous cell carcinoma, thereby histopathology is mandatory for the diagnosis of this lesion. The lesion although being relatively common, still has a lot of ambiguity. The ambiguity is in terms of its etiology, growth potential, biological behavior (recurrence), histogenesis of its cells, and its treatment. The entity further holds significance because of its notorious behavior and high tendency to recur. This is a case report of a 30-year-old female patient with history of swelling in the lower anterior region of jaw since 1 year. After complete excision of lesion, lesion reoccurred after few months.

Lateral periodontal cysts (LPCs) are developmental in origin and are typically seen in the canine-premolar area in the mandible and less commonly in the maxilla. Reported rate of incidence of LPCs is less than 1%, and LPCs represent only 0.8% of entire central cysts of the maxillary bone. Despite its unique clinical and radiological presentation, it is finally diagnosed due to its unique histological characteristics. Here, we present one case with characteristic findings. The routine hematoxylin and eosin–stained sections revealed reduced enamel epithelium-like cystic lining that is made of thin, nonkeratinized stratified squamous epithelium along with some epithelial plaques. The clinical-radio-pathological correlation affirmed the diagnosis of LPC. The pathogenesis of LPC has been discussed.